Getting somewhere with setting it up now, loaded the default profile via MyHarmony and it works nicely within XBMC. Installed the Chrome Launcher add on and added both Netflix and Hulu. Selecting either from the add on in XBMC launches them, but I then run into a problem that while I can scroll up and down, I can't actually select any content to play. I also cannot get back to XBMC without a keyboard (although I think for this if I can map CTRL + W) that should work to get me back into XBMC.
I was also able to launch into YouTube from XBMC, navigate with the remote, search for a video and play a video with the remote. Works really nicely, just need to figure out how to be able to search/select/play within Netflix and Hulu and swap back to XBMC and I am all set. Time to read up on mapping some keys.
Awesome product, and at a good price!!