I am trying to get the same thing working. Logitech 650, Windows 10, GUI V2.2.2, and the newer aluminum chassis Flirc. I tried mapping the full keyboard wake and media center wake/suspend keys to the 1 and 2 buttons of the Logitech 650 just for testing purposes (so that hitting the power on and power off buttons don't turn of the TV). Neither of the functions appear to work. I hope I can get this figured out, as this is the primary reason I bought the Flirc. Any thoughts on how to troubleshoot this?