I'm having the same problem, which has started a week or so a go, on my Windows 10 PC. It was previously working so maybe it was the Anniversary Update? To summarise: 1) Sleep detection enabled. PC will not sleep when being sent the CTRL-ALT-S shortcut via Flirc remote to sleep the machine (this is a shortcut in my Start Menu). PC wakes fine from sleep using mapped Wake command on remote. 2) Sleep detection disabled. PC will sleep when being sent CTRL-ALT-S via FLirc remote. PC will not wake using mapped Wake command :( So, looks like something has broken sleep detection.