I'm having the same issue.
Here is my system configuration :
Alienware Alpha R2 (mini PC)
Windows 10 Home (with all latest updates)
I have a dongle for a wireless Logitech K400+ keyboard in the first usb port in front (see photo)
The Flirc dongle is connected to the second usb port in front
BIOS configured with "Wake from USB" enabled (I successfully tested the wake function with keyboard connected to the PC)