I used the "Microsoft MCE Keyboard" on my Harmony 650. But...in looking at the setup for my DVR setup I am using mostly Flirc IR buttons. (Not sure when I changed that) The Blue button on Flirc is the one that controls the Home function. pressing "Left Win-Key + Enter" on keyboard or via flirc is the "Home" button On custom key combinations I just use "full Keyboard" in the Flirc software and then use the mouse to select the keys I want to program and then press the IR key I want to use.